Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells.
Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex.Its deficiency in mouse leads to embryonic death at E11.5.CERT deficient embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrotic cell death.In the current study we examined the e